Allopregnanolone

Allopregnanolone Sparks Interest in New PMDD Treatment

Allopregnanolone is all over the place these days. We have seen several different allopregnanolone derivatives being used to treat postpartum depression (PPD). Last year, intravenous brexanolone (Zulresso) was approved by the FDA as the first treatment specifically for postpartum depression. An oral version of allopregnanolone, called zuranolone, is also being pursued as a treatment for… Read More »

Oral Allopregnanolone Analogue for Postpartum Depression Treatment

In 2015, we first reported on SAGE-547 (SAGE Therapeutics), a new medication for the treatment of postpartum depression (PPD). SAGE-547, now called brexanolone, is a neurosteroid, an analogue of allopregnanolone and an allosteric modulator of GABAA receptors. Since that time, Sage Therapeutics has conducted three randomized controlled trials, enrolling a total of 247 women diagnosed… Read More »