The use of Reishi as an herbal remedy dates back longer than any other medicinal mushroom in historic literature. The first written record can be found in Shen Nong’s Herbal Classic, dating back two thousand years. Reishi (a.k.a. Ganoderma or Ling Zhi) is often considered a panacea ” cure-all ” in Traditional Chinese Medicine. While it may not be literally accurate to refer to Reishi as a cure-all, the fact that it appears to act as an inflammation modulator may be one of many reasons for its age-old veneration in the Orient.
In fact, Chinese medical practitioners have been prescribing Reishi extract for ages in cases of arthritis, bronchitis and other conditions involving any type of inflammation. Modern research in Asia as well as in America and Europe confirm the validity of these uses. Out of 19 papers used for this article, 17 reported positive results in the use or Reishi extract for arthritis. Only two were studies were inconclusive, both of which were conducted by the same research team. (1,2)
An American study conducted in 1993 by Lin et al. concluded that a water extract of Ganoderma lucidum (Reishi) demonstrated “significant anti-inflammatory activity.” (4) A study out of India ten years later found that an extract of Reishi decreased inflammation in conditions of acute edema and chronic edema by 56% and 60%. (3) Seven additional research papers were found during the writing of this article that all concluded that Reishi is a potent anti-inflammatory medicinal mushroom. (5,6,7,8,9,10,11)
Other research has been conducted on Reishi extract that relate specifically to arthritis. In 2006, Kenneth Blum et al. published findings in support of both the effectiveness and safety of using Reishi extract for “joint health,” providing “clinical evidence” to back up their claim. (12)
Also that same year, a Chinese study by Xi Bao et al. came to the conclusion that Reishi plus another medicinal herbal remedy commonly used in China seemed to have a “beneficial immunomodulatory effect” on arthritis. (13)
Just how Reishi accomplishes its beneficial influence on arthritis may have been stumbled upon by Ho et al. in 2007 (14) when they discovered that GL-PP [Ganoderma lucidum polysaccharide peptide] helped to significantly reduce one of the causative agents of rheumatoid arthritis known as RASF, short for “Rheumatoid Arthritis Synovial Fibroblasts.”
Five additional studies are included in the references that report positive findings between Reishi and arthritis. (15,16,17) One goes so far as to state that Reishi shows favorable results when compared to prednisone, and is free from the side effects. (18) In extension of this, a separate study also found that not only was Reishi extract free of the side effects of prednisone, it could also help balance the existing side effects of prednisolone* such as cell toxicity and proteinuria. (*Prednisolone is the active compound of prednisone. The liver breaks down prednisone and converts it to prednisolone.) (19)
In conclusion, the body of research does seem to support the use of Reishi extract in cases of arthritis. Remember that it is important to always work with a licensed medical practitioner when using any herb for medicinal purposes.
Name clarification: The Japanese name Reishi includes many closely related species. By far the most prevalent is Ganoderma lucidum (Common Reishi or Red Reishi), a species rare in the U.S. but common in South East Asia. The English common name for Ganoderma lucidum is Varnished Conk. In China, its known as Ling Zhi.
Several closely related species of Ganoderma also go by the name of “Reishi”. Most common of these are the Hemlock Reishi (Ganoderma tsugae) found on Hemlocks in the Appalachian Mountains, and the Chinese species “Black Reishi” (Ganoderma sinense). Less common are Ganoderma resinaceum (sometimes called “Red Reishi,” although that name is more often used for G. lucidum), Ganoderma neo-japonicum (no common name other than “Reishi”), and Ganoderma japonicum (Purple Reishi).