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Bad case of the flu? Antiviral medications, such as oseltamivir Tamiflu or zanamivir Relenza, may reduce symptoms and help you recover from the flu a day or two earlier. But oseltamivir came under fire a few months ago for a lack of effectiveness. I suspect this is due to a significant number of people who started therapy after their flu symptoms had been going on for more than two days,” says Dr. Paul Sax, an infectious disease specialist and Harvard Medical School professor. Antivirals must be started within two days of the onset of symptoms. The interference helps keep the virus from leaving one cell and infecting others. But given the WHO’s actions, should we still use antivirals?