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The disparity between elimination half-life and duration of action for some conditions may be partially explained by rapid shifts in distribution of diazepam out of the CNS. The risk or severity of adverse effects can be increased when Diazepam is combined with Barbital. Moderate Use caution when administering ivacaftor and diazepam concurrently because patients may be at increased risk for adverse effects from diazepam. The conclusion that a patient experienced such unique episodes of seizure activity was based on historical information. The dose of any opiate agonist administered with parenteral diazepam should be reduced by at least one-third. Diazepam may increase the central nervous system depressant CNS depressant activities of Buprenorphine. Skip to Content googletag.